Multimodality approach by cardiac magnetic resonance and biological markers in left ventricular non-compaction with heart failure with preserved ejection fraction - revealing the unknown

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): PN-III-P1-1-TE-2016-0669, within PNCDI III Background Left ventricular non-compaction (LVNC) is associated with an increased risk heart failure (HF). The presence a real LVNC HF preserved ejection fraction (HFpEF), still controverted. Methods We evaluated prospectively 42 patients HFpEF, 21 (61 ± 9 years) and without (LVC), aged factor matched, by cardiac magnetic resonance (CMR) 1.5T. diagnosis was confirmed Petersen Jacquier criteria (NC/C ratio the percentage NC myocardium). performed myocardial T1 mapping (normal value 950 21ms). calculated mean all native (T1mean), also for apical (apicalT1) basal segments (basalT1). ECV mean, apical. All had NTproBNP biomarkers systemic inflammation (hsCRP, IL6, cystatin C sST2), endothelial dysfunction: VCAM, von Willebrand (vWf), vWF metalloproteinase-ADAMTS13, fibrosis: vascular peroxidase (VPO), Galectin-3. Results In LVNC, NC/C 2.9 0.5 mm myocardium 24.41 8.8%. significantly higher T1apical, ECVmean, (Table) comparison LVC group, suggesting extensive fibrosis in group fibrosis. Inflammatory markers were similar between groups, lower values ADAMTS13, dysfunction, Galectin-3, (Table). Galectin-3 correlated positively only apicalT1 (R = 0.49, p 0.04). VPO, promotor (r 0.61, 0.009) whereas 0.62, 0003) VCAM 0.4, 0.05). Native cut off >1021 ms provided highest sensibility specificity to differentiate HFpEF (p 0.002) (Figure). Conclusion have significant NTproBNP, than more non-compacted segments. level correlates on CMR, expressed time. Moreover, dysfunction seems play important role generation LVNC. findings suggests that stand alone condition, not adaptive hyper-trabeculation HFpEF. Table.Comparison groups (pg/ml) Galectin3 (ng/ml) ADAMTS13 T1mean (ms) basalT1 (%) 294 282 8.44 3.45 767.35 335.56 1013.8 31.8 1002.8 27.2 1059 73 26.2 29.6 3.9 163 71 6.67 2.88 962.33 253.78 1003.2 28.1 1004.3 29.5 1007 40 24.3 2.5 24.2 2.7 25.2 2.8 P 0.031 0.048 0.049 0.26 0.865 0.007 0.002 0.033 <0.001 Figure